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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Elevated IgE Levels Sign For Lyme Disease?

My daughter has been ill since January, 2011. Neurologist, Stanford doctors, Infectious Disease specialists have been unable to diagnose. Could Lyme Disease cause elevated IgE - total mid 500 s as well as non-specific brain lesions? Lesions in r frontal and l parietal lobes. Lumbar puncture normal, Immunoblot non-reactive, most labs w/in norm limits. Many sx mimic lyme. Removed 2 ticks, not sure how long before onset of sx, I m guessing w/in 1 month. Thank-you, Jill Stanley
Thu, 28 May 2015
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Pathologist and Microbiologist 's  Response
hi,I did review your concern
Lymes disease can cause elevated IgE.
But elevated IgE is seen in many conditions like parasites infections, certain fungal infections,allergic condition like asthma and atopy and rarely in congenital immunodeficiency like Job's syndrome. With lesions in brain, it could be a parasitic infection and my advice would be serum titers for antibodies to parasites like toxoplasma and cysticerosis and also for lymes disease
If these are negative, then you can consult a immunologist and get her evaluated for immunodeficieny disorder.
I hope this helps
Wish you all the best!
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Is Elevated IgE Levels Sign For Lyme Disease?

hi,I did review your concern Lymes disease can cause elevated IgE. But elevated IgE is seen in many conditions like parasites infections, certain fungal infections,allergic condition like asthma and atopy and rarely in congenital immunodeficiency like Job s syndrome. With lesions in brain, it could be a parasitic infection and my advice would be serum titers for antibodies to parasites like toxoplasma and cysticerosis and also for lymes disease If these are negative, then you can consult a immunologist and get her evaluated for immunodeficieny disorder. I hope this helps Wish you all the best! Thank you for choosing healthcare magic!