Hello dear I understand your concern Hope you used copaxone for multiple sclerosis Copaxone is used to treat multiple sclerosis (MS) and to prevent relapse of MS. Constipation is common in MS. Cause of bowel impairments in MS patients is usually either a reduced gut motility or an impairment in neurological control of defecation. Sometime it could be due to medication used for it. I would suggest to consult your doctor for examination and cut down dose or use in lower dose. Continue to drink plenty of water Take syrup lactulose three times a day Tablet bisacodyl at bed time If not responds then glycerin enema can be used Do regular exercise Drink warm water with added honey before bowel movement Hope this may help you Contact further if follow up needed Best regards Dr. Sagar