I m on Cymbalta, so mg, my doctor put me on it about three months ago, because I had a lot of weight gain with Zoloft. Switching to Cymbalta has helped with the weight gain, but since I ve been on it, I ve had heart palpitations return. I have a history of PVCs and PACs, but they went away after I was put on night-time oxygen concentration over a year ago. I m wondering whether the Cymbalta could be responsible for the PVCs. It s hard to know since I was put on a PPI about the same time. I have good blood work and I had a clean echocardiogram and a clean nuclear stress test three months ago. I have panic disorder, and the palpitations are a not frequent tend to occur more frequently when I exercise, but there is not exceptional pain, nor loss of exercise capacity. They ve also been more frequent in the past week during the run-up to my giving a speech to over a thousand people. These are scary. I know, given my history of PVCs and anxiety and a clean cardiac report, this is probably anxiety, but the Cymbalta is a new factor in the mix, gratefully looking forward to any insight you might have.