Hello and I hope I can help you today. Insulin is used to treat diabetes during pregnancy at all stages and is safe and effective. The disease of diabetes and high blood sugar is the part that is dangerous for the baby, and good glucose control is the best way to ensure a healthy child. Good blood glucose levels should be less that 95 for fasting levels and less than 120 after meals (2 hours). If this is the way your wife checks her sugar, and you test at least 4 times daily, she is under very good control and should not need further adjustment of her insulin if her levels stay at the current level. She should be checking her sugar fasting and then 2 hours after every meal. So in summary, insulin is safe and absolutely necessary for the health of the baby if your wife has diabetes. PLease discuss the dosing regimen with your treating physician on a regular basis and make sure your wife checks her readings at least when she wakes up in the morning and then 2 hours after every meal. She should also write down what she eats so her doctor can also know if any changes need to be made in the diet. I hope this information was helpful and answered your question adequately. Best wishes to you and your wife for the rest of the pregnancy. Sincerely, Dr. Brown