Hi, The drug wellbutrin has Bupropion as the active pharmaceutical ingredient. It is an important is an atypical antidepressant and smoking cessation aid. This atypical antidepressant is devoid of many typical side effects commonly associated with most of the typical antidepressant. Because of its different mechanism of action it is used for many indications apart from depression. This drug is mainly used for depression, anxiety, smoking cessation, sexual dysfunction, obesity and many other indication. One of the common problem with typical antidepressant of sexual dysfunction is not associated with this medication. So when your wife is having this medication than this can lead to decrease in depression and anxiety which ultimately increases the sexual desire. There is no medication available with that will increase the libido. Libido of a person is govern by many factors and if some one is in perfect health physically and mentally than will have the normal libido. So it is important to maintain your health to have a good sexual life. Thanks and take care