Hello. Thanks for writing to us at healthcaremagic You seem to have moderate to severe grade of acne. Acne can recur after seemingly complete cure. The cream you have been using in the past contains clobetasol propionate, which is a superpotent topical steroid. It is not meant to be used for acne because regular use of a potent topical steroid may in turn cause more acne. If I was the treating dermatologist I would have started you on oral as well as topical treatment for acne; topical treatment alone is sometimes not effective on its own to take complete control of acne activity, specially in moderate to severe grade inflammatory acne. Topical treatment of acne mainly revolves around 3 categories of drugs: -Topical antibacterials (Nadifloxacin, Clindamycin); -Topical benzoyl peroxide and -Topical retinoids. Topical antibacterials are mainly given for inflammatory acne (red lesions, papules, pustules and nodules etc). They are antibacterial as well as anti-inflammatory. Similarly, topical benzoyl peroxide is also antibacterial, antiinflammatory as well as keratolytic in its action. Its main use is for inflammatory acne. Topical retinoids are first line treatment in all grades of acne (inflammatory or non-inflammatory). They are comedolytic, anti-inflammatory and therefore prevent formation of new acne lesions as well. Oral antibiotics are usually also combined with topical anti-acne treatment, specially for moderate to severe grade of acne. Commonly prescribed oral antibiotics in acne are either Doxycycline, Azithromycin , Or Minocycline. Finally, I would also like to mention about Oral retinoids (Isotretinoin). Oral retinoids are the most effective anti-acne medication. They are first line treatment for severe grade acne as well as acne which is not responding as expected to traditional anti-acne medications. I would suggest that you seek an appointment with your dermatologist in your region for a visual assessment of the severity of your problem and appropriate treatment. Regards