Liver abscesses are caused by bacterial, parasitic, or fungal organisms. Pyogenic abscesses are the most common but worldwide, amoebae are the commonest cause.
Prognosis of the amoebic liver abscess depends on early diagnosis and treatment with antibiotics improves outcome but mortality rates are still 1-3%.Factors that affect prognosis include presence of shock or disseminated intravascular coagulation
, diabetes, associated malignancy, ineffective surgical drainage.
Amoebic liver abscess
is treated with metronidazole
. 95% of patients with amoebic liver abscess recover with this alone. Most patients show a response to treatment within 72-96 hours. Diloxanide furoate is prescribed for 10 days to eliminate intestinal amoebae after the abscess has been successfully treated.
Treatment of asymptomatic cyst
carriers and good sanitation and water facilities are fundamental in the prevention of amoebic liver abscess. Vaccines are not available.