Hello Mr. Chandra Shekhar, I am sorry that you have not been feeling up to your optimum for so many years. I am hoping that you are in regular touch with your treating professional to gain advice about your medication? I believe that besides medication for depression, stress, anxiety and OCD, you may benefit with an ongoing supportive counseling protocol. Sadness is a common emotion. It’s a ‘customary’ reaction to loss, failure, rejection; all of which are inevitable in everyone’s everyday routine existence. All such situations involve pain and the blues they cause are warranted. But staying sad for too long, letting the sorrow engulf you, and inability to snap out of it is not justifiable. That’s the difference between sadness as a passing emotion; and depression as a disorder that needs attention. You cannot ignore your symptoms because they are affecting your life in totality now. Your continuous mental pain must be seriously influencing the quality of life and the you may actually feel that life is really not worth anything. But you need to move out of this mindset and look around to find things that interest you and give you reason to move on. Sleep, appetite, fatigue, laziness, stomachache, indigestion, diarrhea, and headache; even osteoporosis and cancers are linked to diminished immunity owing to depression and stress. The mind and body work in synch; to get the best outcome, both need to be nurtured and nourished else one or both of them give way and sanity get out of hand. I think you must seek professional help and consider psychotherapy (Cognitive Behavior Therapy-CBT, Rational Emotive Behavior Therapy- REBT). These are time tested to work, and require active participation from your side. Do reach out anytime for further help if needed.