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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Long Does Xanax Stay In Body?

My physician said xanac did not show up on my urine screening. I do have a script and take it daily. What could be the cause of it not showing up? I get tested through pain management monthly for my pain meds and was told the xanac which I list as one of my meds was not showing.
Mon, 4 Jan 2016
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General & Family Physician,  's  Response
Hi,
Thanks for posting in HCM.
I understand your concern.
Xanax contains alprazolam. The drug behaves in the following way:
Following oral administration, alprazolam is readily absorbed and reaches its peak concentrations in the plasma by 1 to 2 hours. The mean plasma elimination half-life of alprazolam has been found to be about 11.2 hours (range: 6.3-26.9 hours) in healthy adults.
80% of alprazolam is bound to serum protein, chiefly albumin.
Alprazolam is extensively metabolized primarily by cytochrome P450 to two major metabolites in the plasma, namely 4-hydroxyalprazolam and α- hydroxyalprazolam. Alprazolam and its metabolites are excreted primarily in the urine.
Hope the information provided would be useful.
All the best.
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How Long Does Xanax Stay In Body?

Hi, Thanks for posting in HCM. I understand your concern. Xanax contains alprazolam. The drug behaves in the following way: Following oral administration, alprazolam is readily absorbed and reaches its peak concentrations in the plasma by 1 to 2 hours. The mean plasma elimination half-life of alprazolam has been found to be about 11.2 hours (range: 6.3-26.9 hours) in healthy adults. 80% of alprazolam is bound to serum protein, chiefly albumin. Alprazolam is extensively metabolized primarily by cytochrome P450 to two major metabolites in the plasma, namely 4-hydroxyalprazolam and α- hydroxyalprazolam. Alprazolam and its metabolites are excreted primarily in the urine. Hope the information provided would be useful. All the best.