Hello,
I can understand your concern for your niece's health.
1) USG says, there is small mass in region of
gallbladder and bile duct which might extend into liver and also there is thickening of bile duct.
2) MRI data says there is small lesion in lower vertebra.
3) Blood tests for tumor markers are slightly elevated.
4) All these three suggest possibility of malignancy of common bile duct (
cholangiocarcinoma).
5) For confirmation she might require a) MRI abdomen with MRCP and b)
Triphasic CT abdomen c) PET-
CT scan to check for spread of tumor if it is confirmed.
6) Confirmation of malignancy would require endoscopic USG guided FNAC from lesion.
7) If it is confirmed that tumor in bile duct has spread in vertebra then only
chemotherapy will help. In absence of spread to vertebra, surgery will give best result.
8) As she also have HIV infection, her immunocompromised and poor general condition will also affect treatment decision making.
Hope I answered your query. If you have any further doubts then I would be happy to help you.
Have a nice day!