hi Thanks for your query i can feel your concerns ESR is a nonspecific test and raised in various conditions like infections,inflammations and malignancy.it may be raised because of polycystic kidneys and as he is diabetic and having high cholestrol is he having fever? i advise to moniter his sugar levels and blood pressure regularlyand start antidiabetic and antihypertensive medications after consulting your doctor Improve his diet.add fresh fruits and vegetables to his diet and avoid junk food ans soft drinks Ask him to drink lot of water check his haemoglobin level.and add iron supplements if it is low i think there is also an elemment of depression.give him more time and try to indulge him in healthy activities like walking, exercise etc.antidepressent medications can be added after consulting your doctor wishing him good health regards Dr.AMNA