After closure of ASD that too 15 years ago no complication or no modification of drugs is needed. Unless she was having documented arrthythmia on EKG which at times can persist. Please reassure yourself and your wife. The usual precaution for a hypertensive individual (as a normal individual, here history of closure of ASD has no role whatsoever) have to be taken. If you are keen you can discuss with your doctor and get risk profile for Ischemic Heart Disease
done as she is approaching the age when hormonal
protection from coronary artery
disease is no longer there. Here one must know that Hypertension
is one of the risk factor for coronary disease.
With Best Wishes
Dr Anil Grover