Hi friend, Welcome to Health Care Magic What is the nature of thyroid – deficiency? What is the nature of the polyp? Also, you have not stated your personal habits, family history, or co-morbidities...which could influence the diagnosis and outcome... Weight is like bank account / The amount in your account comes down when you withdraw more (physical work) and you deposit less (eat less). If the weight is picking up, it only means – the exercise is not enough / the food is more / or both.... See a good dietician - you have to reduce the quantity of your food and change the quality too. You also need regular exercise. For weight reduction, there is no officially approved medicine without side effects. If you can not follow the diet or exercise, the other option is to opt for operation... It is called Bariatric surgery – reducing the size of the stomach - and it has proved benefits. Take care Wishing speedy recovery God bless Good luck