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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Myelodysplastic Syndrome. Taking Zocor. Has Memory Loss. Elevated SGPT Due To Simvastatin?

My husband, age 80, IDDM, CKD stage 3, htn, s/p cabg , myelodysplastic syndrome (on Procrit 60,000 u every 3 weeks) has lost weight over the past year (184 lbs. last Dec.) and 162 lb today. Yesterday his sgpt was 58 (other liver enzymes normal). He has been on 20 mg Zocor daily for years, lipids wnl. He has also experienced short term memory loss over the past 2 years. He has been ordered an abd ct. Can simvastatin be the cause of the elevated sgpt? Should he go off of it (at least for a while) to see if the sx are related? Thank you. email YYYY@YYYY
Fri, 21 Dec 2012
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General & Family Physician,  's  Response
Hi,

Thanks for your query.

Firstly, the SGPT value in your husband has been just over the normal. A value of 58 is still considered normal. It is significant only when increased to 3 folds in the hundreds.

Simvastatin does not cause an elevation in SGPT but has to be used with caution who already have a rise in the SGPT value.

I do not think he should go off it, not for a while too.

The short term memory loss seems to be due to senility and not related to the medication.

Hope I have answered your query.

Regards,
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Have Myelodysplastic Syndrome. Taking Zocor. Has Memory Loss. Elevated SGPT Due To Simvastatin?

Hi, Thanks for your query. Firstly, the SGPT value in your husband has been just over the normal. A value of 58 is still considered normal. It is significant only when increased to 3 folds in the hundreds. Simvastatin does not cause an elevation in SGPT but has to be used with caution who already have a rise in the SGPT value. I do not think he should go off it, not for a while too. The short term memory loss seems to be due to senility and not related to the medication. Hope I have answered your query. Regards,