The immunosuppressant medication you are on for the lupus does not help with the infection. However, over 10 months of E Coli infection is very unusual unless there is a diverticulum in the bladder or some sort of anatomical abnormality that is harboring this bacteria.
Cranberry juice has been shown to be very helpful in preventing recurrent UTIs.
You also need a 9AM cortisol
and 4PM cortisol test and may require a short synacthen test to ensure you do not have secondary adrenal insufficiency
to explain the other symptoms.
I hope you are on Vit D3 and Calcium plus bisphosphonates
to protect against bone loss due to the steroids
Please get in touch with your Rheumatologist
as soon as possible.