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Have Hyperprolacinemia. Taken Bromocriptine, Dostinex, Norprolac. Where Is PRL Produced?
Hello. I have hyperprolactinemia. My high PRL was discovered after I had my son cause I never stopped lactating although I stopped breast feeding after two months. It is on the rise since then. It was 110 when was last time tested in May. Since then I had an op to remove my "prolactinoma". It didnt help. I had Bromocriptine, Dostinex, Norprolac. It didnt help. I had 6 MRIs. It was checked also for macroprolactin, my PRL is >98% monomeric (active) prolactin. Last MRI was done in May this year by a new neuro who removed the diagnosis of Prolactinoma. He said my pituitary is fine, there is no tumour. As I said , I do not respond to meds. Where is my PRL produced ? I have seen many different doctors, no one knows...Maybe you know what causes my hyperprolactinemia? I have hypogonadism, irregular or absent menstruation, and as all those doctors I saw described it - hormonal situation completely out of balance.
Mon, 26 Aug 2013
Hello and welcome to HCM,
Prolactin is secreted by the pituitary gland in health.
An increased level of prolactin is seen in tumors of pituitary gland.
Hypogonadism is due to deficiency of sex hormones..
This can be due to deficiency of FSH and LH hormones which are produced by the pituitary gland.
The history is suggestive of pituitary gland abnormality.
As you have mentioned that MRI is normal, a functional abnormality is suspected.
However, the prolactemia id resistant to any treatment.
There is another condition wherein levels of prolactin are increased and this is paraneoplastic syndrome associated with cancers.
Get a complete body scan to look for any evidence of malignancy.
Hypogonadism can be due to deficiency of FSH and LH or target organ insensitivity to hormones.
You need to consult an endocrinologist to find out the cause of hypogonadism.
Thanks and take care
Dr Shailja P Wahal
Prolactin is secreted by the pituitary gland in health.
An increased level of prolactin is seen in tumors of pituitary gland.
Hypogonadism is due to deficiency of sex hormones..
This can be due to deficiency of FSH and LH hormones which are produced by the pituitary gland.
The history is suggestive of pituitary gland abnormality.
As you have mentioned that MRI is normal, a functional abnormality is suspected.
However, the prolactemia id resistant to any treatment.
There is another condition wherein levels of prolactin are increased and this is paraneoplastic syndrome associated with cancers.
Get a complete body scan to look for any evidence of malignancy.
Hypogonadism can be due to deficiency of FSH and LH or target organ insensitivity to hormones.
You need to consult an endocrinologist to find out the cause of hypogonadism.
Thanks and take care
Dr Shailja P Wahal
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