First of all, let me assure you that many patients have their spleen removed, even in the setting of being immunocompromised and don't offer any ill effects. You are correct in that you have a greater risk of post splenectomy
sepsis, but typically in elective splenectomy (planned removal of the spleen) we give 3 vaccines that offset this risk - Hemophaulis influenza
, Streptoccoccus pneumonia
, and Neisseria
. I believe that you have to have these vaccines repeated every 5 years, and that should cover you for the organisms that could cause infection without a spleen.
You shouldn't have to isolate yourself or take any special precautions after your spleen is removed, as long as you keep up with your vaccines. Your quality of life should be unchanged, and most surgeons in the US will do these procedure laparoscopically, meaning it should be done with small incisions
I hope I have answered your questions. Please feel free to contact me if you have any further questions or if you feel I haven't addressed your question adequately.