Your wife's both knees were replaced 8 yrs back - probable cause is due to over weight, old age and deficiency of calcium and vitamins
leading to severe osteo arthritis
. Urinary infection got cleared- advise to take plenty of water. The present Pain in the knee joint, wrists and shoulder may also be due the above said reasons. After knee joint replacement
some amount of difficulty in walking will be there and that too with over weight. Reduction of weight, lipid reducing tabs, vitamins will be helpful. For cold
avoiding dusty atmosphere, allergic items, cold items is advised If necessary consult orthopedic surgeon and investigate for the degree of arthritis in other painful joints and treat accordingly.