Hi and welcome to HCM.
these are symptomatic therapy which sometimes isnt efficient and you may need surgical procedure to exscise anal fisure. This is the last option but also this is the only permanent solution. you should also regulate your diet and take stool softeners,have sitz baths,use steroid
creams if necessary.antibiotics are helpful only when there is bacterial infection and it wont cure primary disease.
Wish you good health.Regards