Hello, damaricadeville, I see that you have been suffering from GERD or acid reflux problems. You tell us that you had upper and lower GI x-rays that were reportedly normal. That means, at least they did not see a big ulcer or narrowing of the esophagus etc. I am not sure if you ever had an endoscopic examination from a gastroenterologist who can take a good look at the lining of the esophagus and , stomach and doudenum to rule out small ulcers or signs of inflammation. He would also do a tissue sample or a biopsy from the sophagus and stomach lining. The biopsy would also show if you have a bacteria called Helicobacter Pylori (H.pylori) which is associated with gastritis and ulcer. Also, if you have not had a sonogram of the gallbladder, I suggest you get that done. Gallstones can cause similar symptoms. Protonix is a good PPI (Proton Pump Inhibitor) like others, and has to be taken properly. Best time to take would be about an hour and a half before your main meal of the day. Sometimes, you may have to take it twice a day for relief of symptoms. If you still don t get relief, you may have a condition called Non erosive reflux disease (NERD) which does not respond well to PPI therapy. You may need additional studies including stomach acidity test and also check the contractions of the stomach (Motility). But, I would recommend endoscopy & biopsy if you have not had one. Wish you well.