One of the concerns would be angina, or low blood supply to the heart with exertion; there are many risk factors, including prior chemo and amyloidosis
itself; other concern would be degeneration of the aortic valve
. I agree that touching base with PCP is warranted and perhaps he would benefit from an exercise stress echocardiogram
to look into further.
Dr Brenes-Salazar MD
Mayo Clinic MN