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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Had CVT In Brain. High Cholesterol And Tryglyceride Levels. Are These Related? Any Blood Disorder?

hi doctor,
my history
1. i had CVT(VENUS THROBOSIS) in my brain 20 months back.the cause told me to me was increased homocysteine( as high as 80) and vitamin b12 deficiency.i recovered from it and was on acitrom for sometime till i stopped it seeing my INR normal.

2. 2 months back i had a lot of weight gain so i got tested.i found abnormal high increase of ldl chloresterol and tryglyredies 195 and 224 respectively.my liver functions were also dearanged--asparate as 61 and alaninne se 135.

3.i again got my homocystine checked and found it high as 39.Are these things related....??....
is there some problem in my blood..i am just 25 yrs old....please advice me.

the gastroentorolist has suggested me atorva(once a day),evion(twice a day),heptral(3rice a day),zevit(2wice a day)..for one month......is the treatment correct...

what else can i do??....am i prone to blood clots again....should i go for MRI.....SHOULDNT I HAVE STOPPED ACITROM AT THE WRONG TIME??....can i have heart atack..will i be ok?
Thu, 23 May 2013
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Critical Care Specialist 's  Response
Hi
Thanks for posting query
CVT in25 year old person may be due to hypercoagulable state ( abnormal increase tendency of blood to form clot) by looking at your tests report it seems you have not completely evaluated for hypercoagulable state. Of course increase homocysteine level is associated with hypercoagulability but it level may increase in the presence of Low Vit B12.
There set of test we use to work up to hypercoagulable state- Apart from homocysteine level are ANA, proein C, ProteinS, factor V Leiden, Antithrombin III, Lupus anticoagulant, Antiphospholipid antibodies
Depending upon cause further treatment will be planned
I am not able to understand why you stopped INR. By giving Acitrome we target INR in the range of 2-3 which is abnormal when you look at the lab report range (1-1.5) but to achieve this abnormality is target of treatment. Once Acitrome is started it should be discontinued only when we are certain episode of clot formation is temporarily phenomena not a permanent hypercoagulable state. Discuss with your treating doctor
According to your lab reports there are risk factor for heart attack (that does not mean you will definitively have) and hypercoagulable state will add to problem
Hope this answers your query. If you have additional questions or follow up queries then please do not hesitate in writing to us. I will be happy to answer your queries.
Dr Jeetendra Sharma
Senior Consultant Critical care Medicine.
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Had CVT In Brain. High Cholesterol And Tryglyceride Levels. Are These Related? Any Blood Disorder?

Hi Thanks for posting query CVT in25 year old person may be due to hypercoagulable state ( abnormal increase tendency of blood to form clot) by looking at your tests report it seems you have not completely evaluated for hypercoagulable state. Of course increase homocysteine level is associated with hypercoagulability but it level may increase in the presence of Low Vit B12. There set of test we use to work up to hypercoagulable state- Apart from homocysteine level are ANA, proein C, ProteinS, factor V Leiden, Antithrombin III, Lupus anticoagulant, Antiphospholipid antibodies Depending upon cause further treatment will be planned I am not able to understand why you stopped INR. By giving Acitrome we target INR in the range of 2-3 which is abnormal when you look at the lab report range (1-1.5) but to achieve this abnormality is target of treatment. Once Acitrome is started it should be discontinued only when we are certain episode of clot formation is temporarily phenomena not a permanent hypercoagulable state. Discuss with your treating doctor According to your lab reports there are risk factor for heart attack (that does not mean you will definitively have) and hypercoagulable state will add to problem Hope this answers your query. If you have additional questions or follow up queries then please do not hesitate in writing to us. I will be happy to answer your queries. Dr Jeetendra Sharma Senior Consultant Critical care Medicine.