Hi there ~
Cracked lips are mostly due to dehydration
and loss of moisture in your lips. It may also be due to vitamin deficiency
which can be easily treated with supplements. I also think that there is cause for concern with regards to fatigue
and this needs psychiatric care. I hope your sister visits with a mental health practitioner as well as a gynecologist for the menopausal issues. I hope this helped.
Take care and have a lovely day!