Thanks for your query.Based on the facts that you have posted it appears that your brother has Severe Urinary Tract Infection
. Please get following test done.
1)Routine Urine test
2) Urine culture and sensitivity.
scanning of Kidney ureter and Bladder.
Take some antibiotics like Ciprofloxacin
along with urinary antiseptic like Nitrofuantoin twice daily with urine alkaliser like Citralka.Get prescription of the drugs from your family Physician.
Once you get the culture report switch on to proper antibiotic as per culture report.
Advice of a qualified Urologist
will be of much help.