Thanks for posting your query.
Your wife suffering from rheumatoid arthritis
which is an autoimmune arthritis
The drugs HCQs and Folitrax are Disease modifying antirheumatoid drugs.
If your wife have no any relief she can switch to another DMRD or Biologicals.
It is an autoimmune disease
so it is not completely removable and medicine should be taken regularly for long time.
Hope I have answered your query. Let me know if you have more concerns.