For long standing Diabetes
possibilities are many but important one are kidney failure or nephropathy,any cardiac pathology as they may no have chest pain
and develop heart problem,or a infection causing asthma like problem. dehydratin due to loose motions or vomiting
which may cause elevation of creatinine
level. She must be checked for these possibilities and after diagnosis treated accordingly. What is her age and drugs used for control of diabetes and is she has high BP.