Minoxycline, in the tetracycline family, is not mentioned in my Food Medication Guide as a cause of increased cholesterol or lipids. Cotrim, also an antibiotic, shows no relation to increased cholesterol although both should be taken cautiously if kidney impairment present or diabetes. With Rifampicine, no mention of cholesterol, but like the other two meds, it does caution use with liver disease and/or to monitor liver function. The liver can contribute to elevated cholesterol. Furthermore, did you know that the increase in cholesterol levels is related to the actual Lyme disease and as far as medications go, treatment meds should aim for selections that are least damaging to the liver. So, to answer your question, no, your medications are not elevating your cholesterol. Your lyme disease is responsible for that. I recommend that you follow a low saturated fat diet with adequate monounsaturated fats, no added sugar, low cholesterol. Some literature says that a gluten free diet may help but no evidence based diet exists in our country. Considering a great deal of inflammation is involved, eating a diet high in anti-inflammatory nutrients (blueberries. . .), lean proteins, fish oil may also help the inflammatory battle according to other research. I hope you are satisfied with my consult and I have answered your question. Best wishes, Kathy Shattler, MS, RDN