There is no drug interaction between alcohol and anastrozole. Alcohol does not affect the effectiveness of alcohol. But alcohol consumption is responsible for increasing the risk of fatty liver disease, hepatic fibrosis, hepatitis, liver cirrhosis, certain cancers, raised blood pressure, stroke, peptic ulcer and congenital malformations. It also increases the risk of many family, work and social problems. I advise to refrain from consuming alcohol. If addiction is issue then take her to a de-addiction center where expert treatment will be given. I hope this information will help you. I will be happy if you ask another question Thanks