Thanks for your query.
Stevens Johnson Syndrome
sometimes occurs in Phenytoin [Epsolin] therapy , more commonly in patients with a particular HLA-B allele, HLA-B 1502.It is thought to be a hypersensitivity
reaction affecting skin and mucous membranes.Severe epidermal necrosis occurs.It is a dermatological emergency. The causative drug has to be discontinued [ Epsolin in this case]. Intravenous immunoglobulin
[ IVIG] reduce the hypersensitivity reaction and improve the condition.Supportive care in form of iv fluid,pulmonary care,parenteral feeding
,maintaining warm environment and symptomatic treatment in form of analgesics,topical antiseptics are the main stay.Blood electrolytes should be monitored.Patient should also be under supervision of an ophthalmologist because eye is also involved.For oral lesions antiseptic mouthwash is indicated.
Care should be taken that superinfection
and sepsis does not occur.Culture of blood, urine & skin is indicated if infection is suspected which is a leading cause of morbidity in such patients.
Regular monitoring of patient's condition is needed.
I wish your brother gets well soon.