Hi there ~ I understand your concerns. Marijuana has a lot of effects on the heart and exacerbating PVCs have been reported in some case studies. I believe that alcohol can also make the condition worse in combination with marijuana. The following stimulants, conditions and triggers may increase your risk of premature ventricular contractions: - Marijuana - Caffeine - Alcohol - Tobacco - Exercise - High blood pressure (hypertension) - Anxiety - Underlying heart disease, including congenital heart disease, coronary artery disease, heart attack, myocarditis and cardiomyopathy. I also think that you might need to consult a doctor to make sure that you have nothing serious going on and get yourself educated about the effects of alcohol and THC on PVCs. I hope this helps. Take care and have a lovely day!