Hallow Dear, Increasing blood pressure is one of the side effects of oral birth control pills due to the effects of the hormones present in them. In fact we do not prescribe oral birth control pills to a woman who has high blood pressure. The women on oral blood pressure pills are monitored for their blood pressure. If persistent alarming rise in blood pressure is noted, they are not suitable candidates for oral birth control pills. I feel your wife should switch over to some other method for birth spacing. She may opt for non-hormonal intrauterine devise like CuT or condom. Oral birth control pills or any hormonal method does not seem to be safe for her. I hope this helps you. Dr. Nishikant Shrotri