Thanks for your query.
or as it is commonly known Depo shot is a injection containing Depo Medroxyprogesterone
It is known to cause side effects like menstrual irregularities,pain or cramps in abdomen,fatigue
,weight gain depression
,hairloss,loss of bone density
and many such side effects.
The absent period is a side effect of Depo and even the leg cramps
can be due to it.
It is known that most of the hormonal
and progesterone) are known to cause pain in legs due to risk of deep vein thrombosis
So please consult your doctor and get examined.
Hope this answer is helpful to you.