Thanks for the query to H.C.M. Forum.
As you mentioned in this query that there is progressive depletion of platelets count and also there is enlargement of spleen
as spleen enlargement is very important in this case .
We call this condition as Thrombocytopenia
, may be due to ,
1 Decreased bone marrow
production , diagnosis can be confirmed by blood film from bone marrow aspiration.
2 Increased splenic sequestration as this is evident ( as spleen is already enlarged)
3 Accelerated destruction of platelets as in case of dengue
fever and many other high grade fever. Diagnosis can be confirmed by C B C and file for M P.
In my opinion consult a hematologist
and get his opinion as spleen is also involved .
Good luck. Dr. HET