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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Currently Taking Prozac For OCD, Feeling Tired, Worried About Serotonin-syndrome?

Hi, I am on 80mgs of Prozac for OCD . I have started a huge health change which includes working out. Because I am so tired all the time with Prozac most likely being the reason, I tried some pre work out supplments and a pre work out/ fat burner supplment walked Detonate. They worked great for me, and I had a great work out, great focus. However, at the end of the day, ( 7 hours after supplment) I had a really bad headache . I would love to continue taking this supplment but I m worried about serotonin- syndrome . Please advise?
Tue, 8 Jan 2013
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Psychiatrist,  's  Response
Hello and welcome to Healthcare Magic. Thanks for your query.

Acoording to the manufacturer's information, Detonate supplement contains Dendrobium Extract (Stem), B-Phenylethylamine HCL, Tangerine Extract (Fruit), Caffeine Anhydrous, Green Tea Extract (Leaf), Green Coffee Bean Extract, Asian Ginseng (Root), Black Pepper Extract (As BioPerine®) (Fruit).

Among these ingredients, many are stimulants which act on the sympathetic nervous system and increase the body's metabolism. In addition, Ginseng is a herb which is supposed to have serotonergic properties. Also, it is possible that these supplements can contain other ingredients which are not mentioned in the label.

Now, 80mg of Prozac (Fluoxetine) is a high dose and you have to be very careful while taking other medication or supplements along with it. So, my opinion is that it is better to avoid taking this supplement along with this high dose of Prozac, and a risk of serotonin syndrome cannot be ruled out.

Wish you all the best.

Regards,
Dr. Jonas Sundarakumar
Consultant Psychiatrist
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Currently Taking Prozac For OCD, Feeling Tired, Worried About Serotonin-syndrome?

Hello and welcome to Healthcare Magic. Thanks for your query. Acoording to the manufacturer s information, Detonate supplement contains Dendrobium Extract (Stem), B-Phenylethylamine HCL, Tangerine Extract (Fruit), Caffeine Anhydrous, Green Tea Extract (Leaf), Green Coffee Bean Extract, Asian Ginseng (Root), Black Pepper Extract (As BioPerine®) (Fruit). Among these ingredients, many are stimulants which act on the sympathetic nervous system and increase the body s metabolism. In addition, Ginseng is a herb which is supposed to have serotonergic properties. Also, it is possible that these supplements can contain other ingredients which are not mentioned in the label. Now, 80mg of Prozac (Fluoxetine) is a high dose and you have to be very careful while taking other medication or supplements along with it. So, my opinion is that it is better to avoid taking this supplement along with this high dose of Prozac, and a risk of serotonin syndrome cannot be ruled out. Wish you all the best. Regards, Dr. Jonas Sundarakumar Consultant Psychiatrist