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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Could The Medicine, Simvastatin, Cause Severe Leg Cramps And Temporary Immobility In The Wee Hours?

I experienced , what my doctor diagnosed as a torn cartilage Dec. 13. I was given a cortisone shot and am taking physical therapy 2 a week. This leg has improved and I experience almost no pain. The other leg, however, has been suffering with leg cramps and muscle tightness for the last 4 weeks. The outside of my leg cramps and experiences great pain while I am using the leg. It happens during the night and is almost unbearable to walk on in the morning--at least for the 1st hour out of the bed. It eases off and if I keep moving during the day, I experience very little cramping and pain. It, however, has become sore to the touch and will begin to cramp around several hours after I go to bed. I'm taking Simvastatin and wonder if this could be a side effect. I've been taking it for approximately 3 years.
Fri, 10 Jan 2014
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General & Family Physician 's  Response
Hello
Thanks for the query to H.C.M. Forum.
Simvastatine is a most potent drugs used in HYperlipidaemia and in coronary artery disease ( to reduce risk).
The most common side effect is DOSE RELATED MYOPATHY (myalgis,muscle weakness & dark urine).
As you mentioned that there is severe pain in the leg after night sleep i.e. prolong rest , os this may be due to .
1 Hamper in blood supply to this parts so get in arteriography of this part .
2 Sometimes Vitamin E deficiency causes such type of pain particularly in calf muscles .
So consult a physician and get his opinion.
Good luck.
Dr. HET
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Could The Medicine, Simvastatin, Cause Severe Leg Cramps And Temporary Immobility In The Wee Hours?

Hello Thanks for the query to H.C.M. Forum. Simvastatine is a most potent drugs used in HYperlipidaemia and in coronary artery disease ( to reduce risk). The most common side effect is DOSE RELATED MYOPATHY (myalgis,muscle weakness & dark urine). As you mentioned that there is severe pain in the leg after night sleep i.e. prolong rest , os this may be due to . 1 Hamper in blood supply to this parts so get in arteriography of this part . 2 Sometimes Vitamin E deficiency causes such type of pain particularly in calf muscles . So consult a physician and get his opinion. Good luck. Dr. HET