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Clinical diagnosis of liver, specimen received consisting grey colored tissue. Is it a cancer?

History : Clinical diagnosis of liver , lest lobe mass . Gross : Received specimen consists of multiple pieces of gray colored tissue , soft in consistency , measuring 6 5 1.5 cm . on cut surface yellow , blak and gray solid areas are seen . Summary of specimen : 9/4 IHC staining results : -Hepar : Negative -CK7 : Negative - CD20 : Negative Diagno : Liver mass excision : Poorly differentiated carcinoma ( metastatic probably ) Note : For definite determination of primary origin and rule out of neuroendocrine differentiation IHC staining is necessary . Resident : Dr. NIK NIAZ do i have cancer or not
Asked On : Wed, 13 Mar 2013
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Oncologist, Radiation 's  Response
Liver metastasis is common with gastrointestinal primary cancer. Other possibilities are lung cancer, breast cancer. CK 20 negative result rules out colon primary, Ck 7 negative rules out Lung primary. Other possible markers are GCDFP for breast cancer. In case of no primary tumor indentification, tumor to be called as CUP ( carcinoma of unknown primary) and to be treated with broad spectrum chemotherapy. Consult your oncologist.
Answered: Thu, 14 Mar 2013
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