Hu, Welcome to HCM, Have read your query, the surest route to success in treating acne vulgaris follows 3 steps. First, establish the type and severity of acne. Second, select medication appropriate for the patient’s condition and skin type. In general, patients with oily skin benefit from solutions or gels, while those with dry skin do better with creams, lotions, or ointments. Third, educate yourself about the disease, the different types of medications and their side effects, and expectations for improvement that are realistic. Realistic expectations should enhance compliance and lead to the successful resolution of a chronic debilitating disease. All of which result from a multifactorial pathophysiologic process in the pilosebaceous unit: sebum production, follicular hyperkeratinization, proliferation and colonization by Propionibacterium acnes, and the release of inflammatory mediators. The resulting lesions include noninflammatory open (blackheads) and closed (whiteheads) comedones, as well as inflammatory papules, pustules, and nodules. A variety of medications are available for the treatment of acne vulgaris. Note that most treatment regimens should be used for at least 6 to 8 weeks to judge their effectiveness before considering alternative treatments or adding other agents. Will recommend to visit your clinician or dermatologist before switching or trying any medications. Thanks