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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Child Switched From Focalin To Vyvanse. Having Shortness Of Breath, Tightness In Throat. Reason?

I am a school nurse and have a nine year old who switched from Focalin 15 or 20 mg daily to vyvanse extended release 50 mg on Jan 28, just 4 days ago. He came to the clinic c/o shortness of breath but his lungs are clear with equal breath sounds, HR 70-100 and mostly regular (possible sinus arrhythmia with inspiration/exp) on palpation , BP 110/74, but continues to have SOB and tightness in his throat . He also takes Zoloft 50 mg per day. The father is on his way to pick him up right now. ANy ideas?
Thu, 7 Feb 2013
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Psychiatrist,  's  Response
Hi There, Thanks for asking. With this switching, the dopamine receptor occupancy in his brain has increased, because he is taking 50 mg XR of Vyvance which is substantially more effective than 20 mg of Focalin. Experiencing shortness of breath in the first days of dosage increment is a common side effect which is seen. Most of the time it is improved with gradual increase in the dose. The chance of arrythmia is really low and you should not worry about it, but it is bothersome for the patient and parents. Since he is taking Zoloft as well, which can also cause shortness of breath, this side effect is exaggerated. The formula of Start low, Go Slow would probably work for him initiating Vyvance. I wish for him the best health and performance at school.
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Child Switched From Focalin To Vyvanse. Having Shortness Of Breath, Tightness In Throat. Reason?

Hi There, Thanks for asking. With this switching, the dopamine receptor occupancy in his brain has increased, because he is taking 50 mg XR of Vyvance which is substantially more effective than 20 mg of Focalin. Experiencing shortness of breath in the first days of dosage increment is a common side effect which is seen. Most of the time it is improved with gradual increase in the dose. The chance of arrythmia is really low and you should not worry about it, but it is bothersome for the patient and parents. Since he is taking Zoloft as well, which can also cause shortness of breath, this side effect is exaggerated. The formula of Start low, Go Slow would probably work for him initiating Vyvance. I wish for him the best health and performance at school.