I initially suggest a Sickling test, Hemogram, Peripheral Smear examination to look for evidence of hemolysis
and sickle cells, CRP, RA Factor,ANA and a review 2D Echocardiography
with color doppler study.
What is the response to paracetamol?
Is sleep disrupted because of pain? If so, how frequently?
Is pain worse at any time of the day?
Are there any other symptoms?