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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Treatment For Mastitis Cause Elevated AST Levels?

Hello, I have elevated AST (i.e., 90) and ALT (i.e., 74), no hepatitis, exercise regularly, rarely consume alcohol and have a BMI of 20. I recently had mastitis was placed on clindamycin (300 mg/TID) for a week. Is it feasible the antibiotics are contributing to the elevated levels? Would breastfeeding have any impact? Kind regards.
Mon, 25 May 2015
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General & Family Physician,  's  Response
Hello,
I had gone through your question carefully and can understand your concern very well.

As you were being treated with macrolides like clindamycin for a week and macrolides most commonly acid stable erythromycin estolate leads to hepatitis like features and that can raise AST and ALT levels. Also incidence of hepatitis like features are high in pregnant women.

So in my opinion, because you were pregnant and treated with macrolides (clindamycin), AST and ALT levels can be high due to antibiotics. No need to worry about it, as it will normalize by itself after discontinuation of drug.

I would suggest you to repeat the AST and ALT levels after a week and it will be normal mostly. Don't get stressed and be relaxed. Also continue your breastfeeding, as it will not have any impact on your baby.

Hope this answers your question and let me know directly if you have any further queries.
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Can Treatment For Mastitis Cause Elevated AST Levels?

Hello, I had gone through your question carefully and can understand your concern very well. As you were being treated with macrolides like clindamycin for a week and macrolides most commonly acid stable erythromycin estolate leads to hepatitis like features and that can raise AST and ALT levels. Also incidence of hepatitis like features are high in pregnant women. So in my opinion, because you were pregnant and treated with macrolides (clindamycin), AST and ALT levels can be high due to antibiotics. No need to worry about it, as it will normalize by itself after discontinuation of drug. I would suggest you to repeat the AST and ALT levels after a week and it will be normal mostly. Don t get stressed and be relaxed. Also continue your breastfeeding, as it will not have any impact on your baby. Hope this answers your question and let me know directly if you have any further queries.