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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Overdoes Of Trazadone Pills Cause Side Effects In Patients With Kidney Failure?

my mom just got taken to the hospital and has liver and kidney failure now and she overdosed on trazadone sleeping pills and morphine pain pills and was wondering if she could die or have lasting effects from this.... thanks. i have been dealing with these problems all of my life and i am 38yrs old.
Tue, 28 Oct 2014
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General & Family Physician 's  Response
Hi,

Trazodone undergoes breakdown and metabolism in the liver. The metabolites, at least one of which is pharmacologically active, are excreted by the kidney. However, elderly patients are more likely to have hyponatremia (low sodium in the blood), which may require caution in patients receiving trazodone. Therapy with trazodone should be administered cautiously in patients with significantly impaired renal or liver function. Since you have written about over dose, it is important to study blood tests involving liver and kidney functions. Sudden death may not happen with an occasional overdose but long term effects of several incidents involving overdose can be harmful.
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Can Overdoes Of Trazadone Pills Cause Side Effects In Patients With Kidney Failure?

Hi, Trazodone undergoes breakdown and metabolism in the liver. The metabolites, at least one of which is pharmacologically active, are excreted by the kidney. However, elderly patients are more likely to have hyponatremia (low sodium in the blood), which may require caution in patients receiving trazodone. Therapy with trazodone should be administered cautiously in patients with significantly impaired renal or liver function. Since you have written about over dose, it is important to study blood tests involving liver and kidney functions. Sudden death may not happen with an occasional overdose but long term effects of several incidents involving overdose can be harmful.