Hello doctor, My name is Anna I m 32 years old. 3 years ago after birth of my first baby daughter I was diagnosed with severe panic disorder ( I had all the symptoms including depresonalisation and derealization). I was treated with Citalopram ( 20 mg increased to 40 mg) and Hydroxizine. Since 2 years I have been feeling OK, coping well with even severe stress, however I m still on 40 mg of Citalopram. My problem begun 6 months ago when I was diagnosed with erosive esophagitis and helicobacter pyroli and needed to take medications (pantoprazole, metronidazole, amoxicillin) which I discontinued due to depressive mood and anxiety symptomes (heart palpitations). I must add here that taking any drug means a lot of stress for me, especially when it comes to side-effects. For a last couple of months I have been taking Sucralfate which is not of much help for my GERD. Several times I tried to come back to pantoprazole ( the only PPI which does not interact with Citalopram) but felt strongly depressed (irritability, anhedonia) and quickly discontinued the drug (one or two days). I m wondering could pantoprazole realy be a cause of my depressed mood? If so will this side effect elevate with time? And finally is there any way to counterbalance the sideeffects of pantoprazole with other psychiatric medications ( i.e. hydroxizine)? Would H2 blockers which I did not try ( fear of alergic reaction) be any alternative to PPIs? Best regards, Anna