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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Azithromycin Affect Bcp Pills Action ?

Hi..I am on Birth control pill Dronis 20 for the past 9 months.. I took my last pill of current pack on last sunday i.e 25th decemeber 2011 and I will be starting my next pack on 30th december 2011 (coming friday). In the mean while I got very bad cold and I tool azithromycin on sunday (On 25th itself). Before that we did not have sex for the past 3-4 days as I was having lil cold ! and I might get my periods also in 1-2 days. But I heard that Azithromycin stays in the body for several days and kill the effectiveness of BC pill. So after how many days I can have unprotected sex. as I am already on gap period (4 days gap to start another gap), and going to get periods is it ok ?
Mon, 11 Mar 2013
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General & Family Physician,  's  Response
Dronis is a combined oral contraceptive pill containing the estrogen ethinyl estradiol and the new progestin Drospirenone which has an additional antiandrogenic action (devoid of androgenic side effects like weight gain & acne). Azithromycin is a macrolide antibiotic, very effective & does not cause drug interactions like other macrolide antibiotics eg., erythromycin, clarithromycin etc., Some antibiotics like amoxycillin & tetracycline inhibit deconjugation of oral contraceptives & can lead to contraception failure. But azithromycin is safe. Still, to be on the safer side, additional contraceptive precaution should be taken while on it and also for 7 days after stopping as it has extensive tissue distribution & also because it is an erythromycin analog.
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Can Azithromycin Affect Bcp Pills Action ?

Dronis is a combined oral contraceptive pill containing the estrogen ethinyl estradiol and the new progestin Drospirenone which has an additional antiandrogenic action (devoid of androgenic side effects like weight gain & acne). Azithromycin is a macrolide antibiotic, very effective & does not cause drug interactions like other macrolide antibiotics eg., erythromycin, clarithromycin etc., Some antibiotics like amoxycillin & tetracycline inhibit deconjugation of oral contraceptives & can lead to contraception failure. But azithromycin is safe. Still, to be on the safer side, additional contraceptive precaution should be taken while on it and also for 7 days after stopping as it has extensive tissue distribution & also because it is an erythromycin analog.