Hello Sanjay and welcome to HCM
You have not written the age of your wife but by seeing the treatment,it seems that she has severe Osteoporosis
. But needs to see her X-ray knee and clinical examination is must. If these medication does not work and the pain persists or you get relief for a limited time of period than last option we have left is Total Knee Replacement
. Consult your doctor for this that at what stage it should be performed.
These medication helps a lot in pain relief. But with these take some precautions: Avoid climbing stairs as much as you can, only walk in smooth roads, don't sit on bearing weight on feet, do hot fermentation atleast twice a day or do UV rays therapy. Consult your doctor for Physiotherapy
Dr. Dinesh Kumar Bhatia
Health Care Magic