Hello, and I hope I can help you today. Pregnancy symptoms vary widely between women, and many of the same symptoms people associate with pregnancy like spotting, breast tenderness, bloating, nausea and mood changes can also been used by other hormonal factors. In addition, pelvic pain can also have many causes. Therefore, there is no way to know if you are pregnant based on symptoms, and the most common sign of pregnancy is missing your period. However, if your pregnancy tests have been negative, you are not pregnant. Irregular menstrual cycles can be caused by weight abnormalities (both too little and too much body fat), stress, certain medical issues, travel, and even worrying about pregnancy. Your gynecologist can prescribe medication to help your period become more regular or help treat the underlying cause, which can also help relieve your breast tenderness. Decreasing caffeine anf salt intake can help as well. I hope I was able to adequately answer your question today and that my advice was helpful. Best wishes, Dr. Brown