Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
131 Doctors are Online

Anti- GAD elevated levels, moving towards diabetes? Next? What now?

Just received blood test results - routine check as part of insurance policy. Fasting blood sugar normal, HBA1C 5,4%, cholesterol levels normal, C peptid normal - everything normal EXCEPT anti - GAD which was at elevated levels (was given a number of 1,14 vs 0,09 is normal, no units given). Conclusion: I may be on a slippery slope towards Diabetes 1. Is this correct - nod any advice re what to do next?
Asked On : Sun, 13 Jan 2013
Answers:  2 Views:  189
Report Abuse
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Diseases and Conditions
Medical Topics
General & Family Physician 's  Response
Glutamic acid decarboxylase (GAD) is an enzyme that is found within the islet cells of the pancreas.These are the cells that produce insulin in healthy,non diabetic individuals.there is a  report that around 70 percent of patients diagnosed with Type 1 diabetes will test positive for this antibody at the time of diagnosis.However It is important to note that this testing positive for anti-GAD antibodies does not mean that a patient does have Type 1 diabetes; furthermore, having a negative GAD antibody test does not mean that Type 1 diabetes is an incorrect diagnosis. However, a positive GAD antibody test may suggest to a physician that a patient with symptoms of high blood sugar may indeed have Type 1 diabetes.

Since your sugar levels are normal,a positive GAD test suggests that you are at risk of developing diabetes in future.Consult your doctor and get anti insulin antibodies as well as 
Islet cell antibodies estimation done,since two positive in these three tests increase the chance of developing diabetes in near future.
Answered: Sun, 13 Jan 2013
I find this answer helpful
Endocrinologist Dr. Abhay Gundgurthi's  Response
U need to provide ur details in depth. Aas of now there is no recommendation to test for anti GAD antibodies in general population. Isolated anti-GAD positivity doesnt have much significance. But it can predict onset in siblings of type 1 diabetes patients. Lead a healthy life i.e. a balanced diet and regular exercise and periodic blood glucose testing. and it would be worth while to screen for other auto immune disease like thyroid disease and celiac disease.
Answered: Sun, 13 Jan 2013
I find this answer helpful

1 Doctor agrees with this answer

Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]


Loading Online Doctors....
© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor