There is no harm in repeating this cream again but you must consult your doctor and subject yourself for physical examination,if you are getting this anal itching repeatedly.
There can be various causes for this like
Perfumes or chemicals or from toilet paper
Infections like yeast or pinworms
Moisture from diarrhoea
Consumption of spicy and irritating foods
The ultimate treatment would depend upon the cause however you may take following self care methods like
Keeping anal area dry
Avoid using soap locally
Using soft,plain and UNSCENTED tissue paper.