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What Is The Ratio Of BUN To Creatinine?
Question: General question about lab tests. What is BUN? What is BUN/Creatinine Ratio? What does it mean if either is below or above the average reference point?
Brief Answer:
BUN/creatinine ratio is helpful in assessing renal and liver disease.
Detailed Answer:
Hello
Full form of BUN is blood urea nitrogen.As its name suggests,it assess amount of nitrogen present in urea.
BUN and BUN/creatinine ratio is helpful in assessing renal,liver disease etc.Its altered ratio is helpful in assessment that problem is within kidneys or outside the kidneys.
BUN and creatinine are freely filtered in kidneys.BUN reabsorption can be regulated whereas creatinine reabsorption is fixed.
BUN can be formed by many sources including dietary and tissue turnover etc whereas creatinine is mainly formed in muscles.
BUN variations due to protein intake,endogenous protein catabolism,state of hydration,hepatic urea synthesis and renal urea excretion.
BUN/Creatinine ratio is increased means BUN is reabsorbed more as in dehydration,decreased perfusion etc.
Decreased BUN/Creatinine ratio means BUN is not absorbed due to problem in kidneys.
So,it is helpful in assessing source of problem.
Type of amino acids varies in different food.
Hope I have answered your query.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
BUN/creatinine ratio is helpful in assessing renal and liver disease.
Detailed Answer:
Hello
Full form of BUN is blood urea nitrogen.As its name suggests,it assess amount of nitrogen present in urea.
BUN and BUN/creatinine ratio is helpful in assessing renal,liver disease etc.Its altered ratio is helpful in assessment that problem is within kidneys or outside the kidneys.
BUN and creatinine are freely filtered in kidneys.BUN reabsorption can be regulated whereas creatinine reabsorption is fixed.
BUN can be formed by many sources including dietary and tissue turnover etc whereas creatinine is mainly formed in muscles.
BUN variations due to protein intake,endogenous protein catabolism,state of hydration,hepatic urea synthesis and renal urea excretion.
BUN/Creatinine ratio is increased means BUN is reabsorbed more as in dehydration,decreased perfusion etc.
Decreased BUN/Creatinine ratio means BUN is not absorbed due to problem in kidneys.
So,it is helpful in assessing source of problem.
Type of amino acids varies in different food.
Hope I have answered your query.
Further queries are most welcome.
Take Care
Dr.Indu XXXXXXX
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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