Brief Answer: most have no symptoms or complications Detailed Answer: HI, thanks for using healthcare magic Platelets are involved in clotting or preventing excess bleeding. They are also called acute phase reactants which mean they respond to inflammation in the body. High platelet count can be classified as primary or secondary. IT is called secondary when it occurs as a result of another medical condition such as an infection, inflammatory conditions, bleeding and tumor. In secondary thrombosis there are usually no symptoms or complications and treatment is towards the underlying cause. If the platelet count in secondary thrombocytosis (thrombocytosis refers to increased platelet count), aspirin is given if the count goes greater than 1000. This is to reduce the chance of stroke or clotting. Primary thrombocytosis however, where there is no other cause, can cause complications. It can result in clotting in different points of the body or bleeding (even though the numbers are increased, they do not work well). The clots can occur in the heart, legs, kidneys, liver, spleen,lungs. I hope this helps, feel free to ask any additional questions

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