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What Is The Cause And Treatment For Gastroparesis?

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Posted on Mon, 7 Apr 2014
Question: Male age 44. Diagnosed with gastroparesis about 4 years ago. Smoker had all kinds of heart and blood tests done but no answers. Occasionally after eating I get episodes with a blah feeling that starts in my chest, kind of like being in a hot tub too long and then extreme weakness and tired. I have to lay down and fall asleep instantly, but the episodes have become more frequent over the past year, they started slowly about 5 years ago. Sometimes I can go for a month or two, no problem then eat one day and bam it's back. I had one today laid down and woke up but the feeling is still there. It hasn't really gone away this time.
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Answered by Dr. Shafi Ullah Khan (1 hour later)
Brief Answer: needs management and thorough work up for cause Detailed Answer: Thank you for asking! What you are having in symptoms is all due to delayed gastric emptying and retention of food after eating leading to all discomforts and all is explained because of Gastroparesis. I want you to know tht Gastroparesis is mainly due to three main causes. DIabetic, Idiopathic and post surgical. Other causes are radiation therapy, radiofrequency ablation of atrial arrhythmias, gastric ischemia from celiac artery occlusion or the median arcutate ligament syndrome, paraneoplastic influences, connective tissue diseases (scleroderma, systemic lupus erythematosus, polymyositis), Chagas disease, neurologic disorders (Parkinson's disease, stroke, dysautonomia syndromes, multiple sclerosis, spinal injury, neurofibromatosis, peripheral nerve disorders), eating disorders, pregnancy, and other hormonal dysregulation (hypothyroidism, hyperparathyroidism, Addison's disease), Crohn's disease, pancreatic disease, and other functional bowel disorders, and dysmotility syndromes. As you are non diabetic it makes it idiopathic( Unknown cause) gastroparesis unless a detailed thorough work up rules out every other possible cause which is more resilient to handle. Try some Advances in gastric emptying testing include wireless motility capsules and nonradioactive breath tests to sort out. new prokinetics (ghrelin agonists), Antidepressants, Antiemetics and next generation gastric stimulators are also shown effective.Caloric intake averages less than 60% of daily recommendations and vitamin (A, B6, C, K) and mineral (iron, potassium, zinc) deficiencies are prevalent and that is why you need to be in constant touch with your dietitian for nutritional support. Keep the diary of The Gastroparesis Cardinal Symptom Index (GCSI) and rate your symptoms daily from Zero to to five( Very severe). They help in management. You need dietary measures, medications that accelerate emptying or blunt vomiting, nonmedication interventions, and psychological therapies. Try consuming frequent small meals and avoiding roughage and high fat foods. However, a recent survey noted that gastroparetics ingested 1.4 meals daily and only 13% complied with fat restrictions. Gastrokinetic and Antiemetic Therapies like metoclopramide, Proclorperazine, Serotonin 5HT3 Antagonist, Dopamine receptor 2 agonists like domperidone, erythromycins and many others. If the medicines are not responding then step up to consider some surgical options like 1)pyloric botulinum toxin injection and 2)gastric electrical stimulator implantations 3)Jejunostomy feedings and 4)TPN. Stay in touch with your psychiatrist for support and don't lose hope. you can do it. I hope it helps.take care and dont forget to close the discussion please. May the odds be ever in your favour. S Khan
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shafi Ullah Khan

General & Family Physician

Practicing since :2012

Answered : 3613 Questions

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What Is The Cause And Treatment For Gastroparesis?

Brief Answer: needs management and thorough work up for cause Detailed Answer: Thank you for asking! What you are having in symptoms is all due to delayed gastric emptying and retention of food after eating leading to all discomforts and all is explained because of Gastroparesis. I want you to know tht Gastroparesis is mainly due to three main causes. DIabetic, Idiopathic and post surgical. Other causes are radiation therapy, radiofrequency ablation of atrial arrhythmias, gastric ischemia from celiac artery occlusion or the median arcutate ligament syndrome, paraneoplastic influences, connective tissue diseases (scleroderma, systemic lupus erythematosus, polymyositis), Chagas disease, neurologic disorders (Parkinson's disease, stroke, dysautonomia syndromes, multiple sclerosis, spinal injury, neurofibromatosis, peripheral nerve disorders), eating disorders, pregnancy, and other hormonal dysregulation (hypothyroidism, hyperparathyroidism, Addison's disease), Crohn's disease, pancreatic disease, and other functional bowel disorders, and dysmotility syndromes. As you are non diabetic it makes it idiopathic( Unknown cause) gastroparesis unless a detailed thorough work up rules out every other possible cause which is more resilient to handle. Try some Advances in gastric emptying testing include wireless motility capsules and nonradioactive breath tests to sort out. new prokinetics (ghrelin agonists), Antidepressants, Antiemetics and next generation gastric stimulators are also shown effective.Caloric intake averages less than 60% of daily recommendations and vitamin (A, B6, C, K) and mineral (iron, potassium, zinc) deficiencies are prevalent and that is why you need to be in constant touch with your dietitian for nutritional support. Keep the diary of The Gastroparesis Cardinal Symptom Index (GCSI) and rate your symptoms daily from Zero to to five( Very severe). They help in management. You need dietary measures, medications that accelerate emptying or blunt vomiting, nonmedication interventions, and psychological therapies. Try consuming frequent small meals and avoiding roughage and high fat foods. However, a recent survey noted that gastroparetics ingested 1.4 meals daily and only 13% complied with fat restrictions. Gastrokinetic and Antiemetic Therapies like metoclopramide, Proclorperazine, Serotonin 5HT3 Antagonist, Dopamine receptor 2 agonists like domperidone, erythromycins and many others. If the medicines are not responding then step up to consider some surgical options like 1)pyloric botulinum toxin injection and 2)gastric electrical stimulator implantations 3)Jejunostomy feedings and 4)TPN. Stay in touch with your psychiatrist for support and don't lose hope. you can do it. I hope it helps.take care and dont forget to close the discussion please. May the odds be ever in your favour. S Khan